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Securement and fundamental investigation of therapeutic gut microbes against intestinal inflammation
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创建时间：
2023-03-02
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Ulcerative colitis (UC), is the main subtype of inflammatory bowel disease (IBD). Although the availability of many effective therapeutic strategies, some patients still either fail to respond in addi
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Safety assessment of Butyricicoccus pullicaecorum. Butyrate producers as potential next-generation probiotics: safety assessment of the administration of Butyricicoccus pullicaecorum to healthy volunteers
Advances in gut microbiota research have triggered interest in developing colon butyrate producers as niche-specific next-generation probiotics, targeted at increasing colon butyrate production and co
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Faecalibacterium prausnitzii Strain HTF-F and Its Extracellular Polymeric Matrix Attenuate Clinical Parameters in DSS-Induced Colitis
A decrease in the abundance and biodiversity of intestinal bacteria within the Firmicutes phylum has been associated with inflammatory bowel disease (IBD). In particular, the anti-inflammatory bacteri
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DIME study: Safety, dose-response and efficacy of treatment with Anaerobutyricum soehgenii on glucose metabolism in human subjects with metabolic syndrome
The intestinal microbiota has been implicated in insulin resistance, although evidence regarding causality in humans is scarce. We herefore performed a phase I/II dose-finding and safety study on the
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Genome sequencing and assembly of antibiotic-resistant isolates from the patients before and after the administration of study drugs of RBX2660 and placebo.
In this study, we explored the effect of a microbiota-based drug RBX2660, a suspension of healthy donor microbiota, on the gut microbiome and resistome of recipients treated for rCDI. rCDI patients re
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