Domino One-Pot Process for the Synthesis of Isobenzofuran-1(3<i>H</i>)‑ones via [Cu]-Catalysis Using Water as the Green Solvent
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An efficient domino one-pot strategy via [Cu]-catalyzed intermolecular “cyanation” of o-bromobenzyl alcohols → in situ intramolecular “nucleophilic attack” → “hydrolysis” is presented, for the synthesis of isobenzofuran-1(3H)-ones. Significantly, the reaction is successfully carried out under environmentally benign conditions, using water as sole green solvent.
创建时间:
2016-02-13



