mtDNA-network data - Parkinson's Disease

mtDNA INDELs modulates neuroinflammation in Parkinson’s Diseases Gustavo Barra Matos1, Camille Sena dos Santos1, Letícia Cota Cavaleiro de Macêdo1,2, Juliana Paiva dos Santos Diniz1,2, Tatiane Piedade de Sousa1, Giovanna C. Cavalcante1, Caio Santos Silva1, Rebecca Lais da Silva Cruz1, Dafne Dalledone Moura2, Andrea Ribeiro-dos-Santos1, Bruno Lopes Santos-Lobato2, Gilderlanio Santana de Araújo1 Author affiliations: 1 Laboratório de Genética Humana e Médica, Federal University of Pará, 66075-110, Belém, Pará, Brazil 2 Institute of Technology, Federal University of Pará, 66075-110, Belém, Pará, Brazil. 3 Laboratory of Experimental Neuropathology, Federal University of Pará, 66073-005, Belém, Pará, Brazil. Correspondence to: Gilderlanio Santana de Araújo Full address E-mail: [e-mail] Abstract Our research studies explored the link between mitochondrial DNA (mtDNA) changes and Parkinson’s disease (PD), particularly in patients who develop levodopa-induced dyskinesia (LID). We sequenced blood samples from 87 individuals in the Brazilian Amazon, including PD patients (with and without LID) and healthy controls. We found that PD patients without LID had more mtDNA mutations, especially in a key mitochondrial region (Complex I). These mutations were linked to lower activity in certain genes (ND4 and ND5), which may contribute to PD progression.