Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C

Crystal Structure of small molecule ARS-853 covalently bound to K-Ras G12C Descriptor: 1-[3-[4-[2-[[4-chloranyl-5-(1-methylcyclopropyl)-2-oxidanyl-phenyl]amino]ethanoyl]piperazin-1-yl]azetidin-1-yl]prop-2-en-1-one, GLYCEROL, GLYCINE, ... Authors: Patricelli, M.P, Janes, M.R, Li, L.-S, Hansen, R, Peters, U, Kessler, L.V, Chen, Y, Kucharski, J.M, Feng, J, Ely, T, Chen, J.H, Firdaus, S.J, Babbar, A, Ren, P, Liu, Y. Deposit date: 2015-12-01 Release date: 2016-01-13 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov, 6, 2016小分子ARS-853与K-Ras G12C共价结合的晶体结构 描述符：1-[3-[4-[2-[[4-氯-5-(1-甲基环丙基)-2-羟基苯基]氨基]乙酰基]哌嗪-1-基]氮杂环丁烷-1-基]丙-2-烯-1-酮、甘油、甘氨酸…… 作者：Patricelli, M.P、Janes, M.R、Li, L.-S、Hansen, R、Peters, U、Kessler, L.V、Chen, Y、Kucharski, J.M、Feng, J、Ely, T、Chen, J.H、Firdaus, S.J、Babbar, A、Ren, P、Liu, Y. 沉积日期：2015-12-01 发布日期：2016-01-13 最后修改日期：2024-11-20 实验方法：X射线衍射（分辨率1.4 Å） 引用文献：《靶向非活性状态的小分子选择性抑制致癌KRAS信号输出》，刊载于《癌症发现（Cancer Discov）》，2016年，第6卷