Knotted proteins representatives list.

List of the knotted protein representatives. CATH [39] and EC [57] codes are indicated where available; the knotted region refers to the PDB residue numbering. The chirality is indicated with a or tag appended to the knot type. CATH domains containing the knot are highlighted in boldface for multidomain proteins. The knot region is defined by taking the strictly knotted protein segment returned by the Protein Knot server [50] and extending it by 20 amino acids on both sides. For protein chain 2p02A, which is not recognised as knotted by the server, the strictly knotted protein segment was identified using the method of ref. [58]. The knot in the last entry (1s1hI) has a probably artefactual origin, see Results and Discussion.