Lung Histopathology Cotton Rats.

Lung histopathology scores from cotton rats immunized with the indicated dose of RSV F (RSV-F) nanoparticles without or with aluminum phosphate adjuvant (RSV-F+alum), live RSV then challenged (RSV+Chal), PBS then challenged (PBS+Chal), or PBS alone. Cotton rats (n = 7 or 8 per group) were immunized on day 0 and day 21 and challenged with RSV virus on day 49. Lung tissues were harvested on day 54 and subjected to histopathology and blinded samples scored for severity on a scale of 0 to 4. Total and mean of all measures per animal for bronchiolitis, perivasculitis, bronchitis, alveolitis and pneumonitis are given.