Single cell RNA sequencing reveals microglia-like cells in cerebrospinal fluid during virologically suppressed HIV

Using single cell RNA sequencing (scRNA-seq) on cerebrospinal fluid (CSF) and blood from adults with HIV, we identified a rare (<5% of cells) subset of myeloid cells that are found only in CSF and that present a gene expression signature that overlaps significantly with neurodegenerative disease associated microglia examination of CSF and blood for human study volunteers, prepared via SeqWell