Modular Total Syntheses of the Marine-Derived Resorcylic Acid Lactones Cochliomycins A and B Using a Late-Stage Nozaki–Hiyama–Kishi Macrocyclization Reaction
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https://figshare.com/articles/dataset/Modular_Total_Syntheses_of_the_Marine_Derived_Resorcylic_Acid_Lactones_Cochliomycins_A_and_B_Using_a_Late_Stage_Nozaki_Hiyama_Kishi_Macrocyclization_Reaction/2219929
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资源简介：
The natural products
cochliomycin A (1) and cochliomycin
B (2), two resorcylic acid lactones obtained from marine
sources, have been prepared in a concise and stereocontrolled manner
from the readily accessible building blocks 4–6. Olefin cross-metathesis, trans-esterification
and Nozaki–Hiyama–Kishi (NHK) macrocyclization reactions
were employed in the key steps. Hydrolysis of the immediate precursor
to cochliomycin B affords the resorcylic acid lactone zeaenol (24).
创建时间：
2016-02-16
