HIV-1 recurrently targets active genes that are positioned in the outer shell of the nucleus and integrates in the proximity of the nuclear pore compartment. However, the genomic features of these gen

NIAID Data Ecosystem40

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid

HIV-1整合

艾滋病药物设计

HIV-1 Integrase Catalytic Core Domain Complexed with Allosteric Inhibitor (2S)-[1-(1-benzyl-1H-pyrazol-4-yl)-3-(3,4-dihydro-2H-1-benzopyran-6-yl)isoquinolin-4-yl](tert-butoxy)acetic acid

NIAID Data Ecosystem20

HIV-1 integration in microglia (ChIP-seq of CTCF-KD/-NT)

染色质免疫沉淀测序

HIV-1整合

We performed ChIP-seq in a microglia cell line (C20) upon CTCF-KD and CTCF-NT (wild-type) to understand the impact of CTCF loss on chromatin and HIV-1 integration pattern in the C20 cell line. ChIP-se

NIAID Data Ecosystem40

List of candidate MRs for each comparison (Control v. NDAD and Control v. AD) in strategy 1 (highly ranked in HIP).

阿尔茨海默病分子机制

主调控因子

MR master regulator, NES normalized enrichment score, HIP hippocampus, AD Alzheimer’s disease, NDAD non-demented Alzheimer diseaseList of candidate MRs for each comparison (Control v. NDAD and Control

Figshare2015-12-03 更新20

Cyclophilin A and CPSF6 regulate HIV-1 integration. Homo sapiens

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