SARS-CoV-2 Mpro in complex with compound 18r inhibitor

SARS-CoV-2 Mpro in complex with compound 18r inhibitor Descriptor: 3-chloro-N-[(2R)-1-({(1Z,2S)-1-imino-3-[(3R)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)-4-methyl-1-oxopentan-2-yl]-4'-methoxy[1,1'-biphenyl]-4-carboxamide, 3C-like proteinase nsp5 Authors: Afsar, M, Bury, P, Olsen, S.K. Deposit date: 2024-04-07 Release date: 2025-04-16 Last modified: 2026-04-29 Method: X-RAY DIFFRACTION (2.08 Å) Cite: Identification and Exploration of a Series of SARS-Cov‐2 M Pro Cyano-Based Inhibitors Revealing Ortho-Substitution Effects within the P3 Biphenyl Group. Acs Med.Chem.Lett., 16, 2025与化合物18r抑制剂结合的严重急性呼吸综合征冠状病毒2型3C样蛋白酶nsp5（SARS-CoV-2 Mpro）。描述符：3-氯-N-[(2R)-1-({(1Z,2S)-1-亚氨基-3-[(3R)-2-氧代吡咯烷-3-基]丙-2-基}氨基)-4-甲基-1-氧代戊烷-2-基]-4'-甲氧基[1,1'-联苯]-4-甲酰胺。作者：Afsar M、Bury P、Olsen S.K.。存档日期：2024-04-07；发布日期：2025-04-16；最后修改日期：2026-04-29。实验方法：X射线衍射（分辨率2.08埃）。引用文献：《系列基于氰基的SARS-CoV-2 Mpro抑制剂的鉴定与探究：P3联苯基团的邻位取代效应》，发表于《ACS药物化学通讯》（Acs Med.Chem.Lett.）2025年第16卷。