The transcription factor Fosl2 controls systemic autoimmunity by repressing FoxP3 during T cell development
收藏NIAID Data Ecosystem2026-05-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP200662
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Purpose: We aimed to charaterise the transfriptional effects of Fosl2 in T cells Methods: We used wt, Fosl2 overexpressing (Fosl2tg) and Fosl2 knock-out (Fosl2ko) CD4+ naive T cells that we stimulated for 24 hours with anti-CD3 and anti-CD28. RNA-was extracted and sequenced using Results: We identified a set of genes whose expression is regulated by Fosl2 in T cells, including Foxp3. Overall design: RNA-sequencing from T cells with overexpression or knock-out of Fosl2.
创建时间：
2021-01-05
