PARP-1/PARP-2 double deficiency results in recurrent early pregnancy loss and decidualization failure in mice

Specifically, we found inhibition of PARP-1 and PARP-2 catalytic activity, or tissue-specific genetic knockout, results in a severe fertility defect. Transcriptomic analyis uncovered that PARP-1;PARP-2-deficient mice have defects in the progression of stromal cell decidualization manifesting in pregnancy failure Overall design: RNAseq libraries were generated from control and knockout implantation sites on gestational days 4, 5, and 6.