Human neuroblastoma cell lines: control vs treated with verlindamycin and ATRA. Human neuroblastoma cell lines: control vs treated with verlindamycin and ATRA

Analysis of differential gene expression in response to treatment of neuroblastoma cell lines (MYCN-amplified SK-N-BE(2)-C and non-amplified SKNAS) with retinoic acid and verlindamycin (a novel polyamine analogue and LSD1 inhibitor). This compound combination was found efficient in inducing differentiation in neuroblastoma cell lines and the goal of this microarray experiment was to analyse which genes and pathways were altered upon this treatment. Overall design: Two-condition experiment for two cell lines: for both SK-N-BE(2)-C and SKNAS treated (verlindamycin+ATRA) vs control