Crystal structure of the Prototype Foamy Virus (PFV) S217H mutant intasome in complex with magnesium and Dolutegravir (S/GSK1349572)

Crystal structure of the Prototype Foamy Virus (PFV) S217H mutant intasome in complex with magnesium and Dolutegravir (S/GSK1349572) Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', 5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3', ... Authors: Hare, S, Cherepanov, P. Deposit date: 2011-05-18 Release date: 2011-07-13 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.49 Å) Cite: Structural and Functional Analyses of the Second-Generation Integrase Strand Transfer Inhibitor Dolutegravir (S/GSK1349572). Mol.Pharmacol., 80, 2011原型泡沫病毒（Prototype Foamy Virus, PFV）S217H突变体整合体与镁离子及多替拉韦（Dolutegravir, S/GSK1349572）复合物的晶体结构 描述：(4R,12aS)-N-(2,4-二氟苄基)-7-羟基-4-甲基-6,8-二氧代-3,4,6,8,12,12a-六氢-2H-吡啶并[1',2':4,5]吡嗪并[2,1-b][1,3]恶嗪-9-甲酰胺，5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3'，5'-D(*TP*GP*CP*GP*AP*AP*AP*TP*TP*CP*CP*AP*TP*GP*AP*CP*A)-3'，…… 作者：Hare S、Cherepanov P 提交日期：2011-05-18 发布日期：2011-07-13 最后修改日期：2023-09-13 实验方法：X射线衍射（分辨率2.49 Å） 引用文献：《第二代整合酶链转移抑制剂多替拉韦（S/GSK1349572）的结构与功能分析》，《分子药理学（Mol.Pharmacol.）》，第80卷，2011年