Metal-Free sp<sup>3</sup> C–H Bond Dual-(Het)arylation: I<sub>2</sub>-Promoted Domino Process to Construct 2,2-Bisindolyl-1-arylethanones
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A molecular I2-promoted sp3 C–H bond dual-(het)arylation protocol was developed for the synthesis of 2,2-bisindolyl-1-arylethanones. Through a logical design, three mechanism-different reactions (iodination, Kornblum oxidation, and Friedel–Crafts reaction) were assembled in a single reactor. A variety of 2,2-bisindolyl-1-aryl ethanones were synthesized from simple and readily available aryl methyl ketones and indoles. In the reaction, metal, base, and ligand were all avoidable.
创建时间：
2016-02-20
