Markers of Autism Spectrum Disorders in At-Risk Toddlers: A Pilot Study

This is the release of MRI data from a study is to learn more about risk factors for autism by studying the behavior and brain functioning of toddlers with early communication delays and typically developing toddlers. Children 12 or 18 months of age with language delays (i.e., no words at 18 months, limited vocalizations at 12 months) and typically developing toddlers may be eligible to participate. This study was conducted at the NIH Clinical Center in Bethesda, Maryland. There was be an initial screening evaluation that included behavioral assessment. Eligible participants then completed a baseline visit that included an overnight sleep study that included Electroencephalogram (EEG) test to measure brain electrical activity, and an MRI scan. Follow-up visits that included behavioral assessment occurred every 6-12 months, depending on age at study entry. The final study visit occurred at 36 months of age and included behavioral assessment, sleep/EEG study, and MRI.