Whole transcriptome profiling of H37Rv- and H37Rv?1759c-infected macrophages.

To explore the regulatory network of noncoding RNAs after M.tb infection and the role of Rv1759c in the infection process, we collected samples of H37Rv- and H37Rv?1759c-infected macrophages and explored the full transcriptome expression profile. We constructed DE-lncRNA/DE-circRNA-DE-miRNA-DE-mRNA regulatory networks during H37Rv and H37Rv?1759c infection. In addition, we first discovered the close relationship between Rv1759c and chemokines during M.tb infection by comparing the transcription profiles of H37Rv and H37Rv?1759c and bioinformatics analysis. Here, our study comprehensively characterizes the ncRNA and mRNA profiles in macrophages infected with H37Rv and H37Rv?1759c, which provides support and new directions for in-depth exploration of ncRNA and PE/PPE family functions during the infection process. Overall design: Explore the Whole transcriptome profiling of H37Rv- and H37Rv?1759c infected macrophages.