Data from: High-throughput generation of block copolymer libraries via click chemistry and automated chromatography

Designing block copolymers for specific applications is challenging
because of the intricate relationship among molecular structure,
self-assembly behavior, and bulk properties, which is compounded by a
large design space that traditionally requires time-consuming, iterative
synthesis. To overcome these challenges, here we report a library-based
strategy leveraging an active ester-based block copolymer and automated
chromatography which enables the high-throughput exploration of broad
compositional and chemical landscapes without requiring sample-specific
optimization. By integrating automated chromatography with robotic
synthesis and orthogonal post-polymerization modification chemistry, we
efficiently generated a diverse library of 90 well-defined block
copolymers from a single as-synthesized “parent” copolymer. This adaptable
method enables efficient access to materials with a wide range of
compositions, molecular weights, functionalities, and properties. By
integrating laboratory automation with click chemistry, these insights
will accelerate the discovery and design of advanced block copolymers for
high-performance applications.