<strong>Streptococcus Pneumonia Hu17 and Influenza (H1N1) Virus Genome Study against Human Genome Sequences – DAVID analysis</strong>

The study was performed to analyze the overlapping of genome sequences in Streptococcus pneumonia Hu17 and Influenza (H1N1) virus against human genome - Homo sapiens Hg38 sequences by BLASTn sequence analysis. Several hits or overlapping nucleotide segments were identified. Between Streptococcus pneumonia Hu17 and Homo sapiens hg38, 287 overlaps were identified, and among influenza H1N1 and Homo sapiens hg38, 124 hits were identified. The corresponding genes associated with the overlapping segments were further analyzed for functional enrichment annotations through the database for annotation, visualisation and integrated discovery (DAVID) software. A wide range of functional significance of these genes was identified, and the results are presented. The results show insights into functional biological activities associated with the respective vaccinations or infections by these microorganisms. <br>

本研究通过BLASTn序列分析，探究肺炎链球菌（Streptococcus pneumonia）Hu17菌株、甲型流感（H1N1）病毒的基因组序列与人类基因组——智人（Homo sapiens）Hg38参考序列之间的同源重叠情况。研究共鉴定出多段比对命中或重叠的核苷酸片段：肺炎链球菌Hu17与智人Hg38之间共鉴定出287处重叠区域，甲型流感H1N1病毒与智人Hg38之间则鉴定出124处比对命中片段。针对上述重叠片段所关联的基因，本研究进一步通过注释、可视化与整合发现（DAVID）数据库软件开展功能富集注释分析，鉴定出这些基因所涉及的多类重要生物学功能，并将研究结果进行了呈现。本研究结果可为解析这两类微生物相关疫苗接种或感染过程中的功能性生物学活性提供参考视角。

搜集汇总

背景与挑战

背景概述

该数据集通过BLASTn序列分析，研究了肺炎链球菌Hu17和H1N1流感病毒基因组与人类基因组（Homo sapiens Hg38）的重叠序列，分别识别出287个和124个重叠片段。利用DAVID软件对相关基因进行功能富集注释，揭示了这些基因在疫苗接种或感染中的功能生物学意义，为理解微生物与宿主相互作用提供了数据支持。