26 significant loci identified by applying Meta-GxE analysis.

Twentysix significant loci identified by applying Meta-GxE analysis of both random effects meta-analysis and heterogeneity testing to 17 mouse HDL studies under different environments containing 4,965 total animals. # studies E denotes the number of studies with an effect on HDL phenotype. # studies N denotes the number of studies with no effect on HDL phenotype. # studies A denotes the number of studies with an ambiguous effect size. Genes in region denotes candidate genes for each locus based on close proximity to the peak SNP and previously suggested role in lipid or apolipoprotein metabolism: Pikfyve (phosphoinositide kinase), Bcl2 (B cell leukemia/lymphoma 2), Apoa2 (apolipoprotein A-II), Agps (alkylglycerone phosphate synthase), Jag1 (jagged 1), Prkci (protein kinase C), Prkci (colony stimulating factor 1 (macrophage)), Hs2st1 (heparan sulfate 2-O-sulfotransferase 1), Fabp3 (fatty acid binding protein 3), Nos1 (nitric oxide synthase 1), Acsl1 (acyl-CoA synthetase long-chain family member 1), Cpe (carboxypeptidase E), Prkaca (protein kinase, cAMP dependent, catalytic, alpha), Acox1 (peroxisomal acyl-coenzyme A oxidase 1), Ppyr1 (pancreatic polypeptide receptor 1), Trib1(tribbles homolog 1), Sqle (squalene epoxidase), Gnmt (glycine N-methyltransferase), Mbp(myelin basic protein), Lrp5 (low density lipoprotein receptor-related protein 5), Htr2c (5-hydroxytryptamine (serotonin) receptor 2C).