Platelets orchestrate the resolution of pulmonary inflammation in mice through Treg repositioning and macrophage education. Platelets orchestrate the resolution of pulmonary inflammation in mice through Treg repositioning and macrophage education

Our study investigates how interactions of platelets with regulatory T cells (Tregs) modulates the transcriptomic profile of Tregs and pro- and anti-inflammatory macrophages in the lung during resolution of pulmonary inflammation. Overall design: Pulmonary inflammation was induced by bacterial pneumonia (K. pneumonia) in mice. Single Tregs and Treg-PLT aggregates were isolated from the brochoalveolar lavage (BAL) on day 5 after induction of pneumonia. Pro- and antiinflammatory macrophages were isolated from the BAL on day 5 after induction of bacterial pneumonia from control and platelet-depleted mice.