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Dysregulation of the Wnt/ß-catenin signaling pathway via Rnf146 upregulation in a VPA-induced mouse model of autism spectrum disorder

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NIAID Data Ecosystem2026-05-01 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP402930
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To investigate the function of RNF146 on gene expression and signaling pathways, we overexpressed RNF146 in mouse prefrontal cortex (PFC) using AAV and performed RNA-seq analysis. We found that genes in Wnt signaling pathway are differentially expressed in RNF146 expressed PFC compared to control. Overall design: 4 RNF146-expressed PFC samples were compared with 4 eGFP-expressed control samples.
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2023-09-01
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