Subcellular-Level Physiological Cisplatin Distribution in the Cochlea

B2FIND2026-04-28 收录

耳毒性机制

药物耳蜗分布

数据链接：

https://b2find.eudat.eu/dataset/3fb05b89-dbea-503c-9409-c9c790ad1509 数据链接链接失效反馈

官方服务：

资源简介：

Cisplatin ototoxicity (CO) contributes to ~0.5 million hearing impairment cases among cancer patients globally each year. The lack of understanding of cisplatin distribution in...

Supplementary Material for: Synergistic Ototoxicity of Gentamicin and Low-Dose Irradiation: Molecular Basis and Clinical Significance

耳毒性机制

辐射与药物协同效应

Background: Inner ear structures may be included in the radiation fields when irradiation is used to treat patients with head and neck cancers. These patients may also have concurrent infections that

Figshare2019-12-13 更新30

Data_Sheet_1_CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing.PDF

耳毒性机制

听力保护策略

Sensory hair cell death caused by the ototoxic side effects of many clinically used drugs leads to permanent sensorineural hearing loss in patients. Aminoglycoside antibiotics are widely used and well

NIAID Data Ecosystem20

Data Sheet 1_Multiple mechanisms of aminoglycoside ototoxicity are distinguished by subcellular localization of action.pdf

耳毒性机制

毛细胞损伤病理

Mechanosensory hair cells of the inner ears and lateral line of vertebrates display heightened vulnerability to environmental insult, with damage resulting in hearing and balance disorders. An importa

NIAID Data Ecosystem10

Subcellular-Level Physiological Cisplatin Distribution in the Cochlea

耳蜗药物分布

耳毒性机制

Cisplatin ototoxicity (CO) contributes to ~0.5 million hearing impairment cases among cancer patients globally each year. The lack of understanding of cisplatin distribution in the cochlea and the mec

DataCite Commons2023-12-12 更新30

Supplementary Material for: Endoplasmic Reticulum Stress Is Involved in Cochlear Cell Apoptosis in a Cisplatin-Induced Ototoxicity Rat Model

耳毒性机制

内质网应激与细胞凋亡

Endoplasmic reticulum (ER) stress arises when excessive improperly folded proteins accumulate in the ER lumen. When ER stress occurs, the unfolded protein response (UPR) is subsequently activated to r

Figshare2017-10-19 更新10

Subcellular-Level Physiological Cisplatin Distribution in the Cochlea

资源简介：

相关数据集