Methamphetamine-induced impairment of memory and fleeting neuroinflammation: profiling mRNA changes in mouse hippocampus following short-term and long-term METH exposure

METH-induced inflammatory responses occur in the early phase and do not further exacerbate with repeated injections. However, RNA sequencing revealed the persistent enrichment of inflammatory pathway molecules, which correlated with worsened behaviors. This suggests that although METH-induced neuroinflammation plays a critical role in learning and memory impairment, the continued enrichment of inflammatory pathway molecules is associated with behavioral outcomes.