WijayaTrairatphisan2021 - Logic-ODE model of stress signaling in DILI
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https://www.omicsdi.org/dataset/biomodels/MODEL2206070001
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资源简介：
We established a comprehensive temporal dynamic response profile of a large set of BAC-GFP HepG2 cell lines representing the following components of stress signaling: i) unfolded protein response (UPR) [ATF4, XBP1, BIP and CHOP]; ii) oxidative stress [NRF2, SRXN1, HMOX1]; iii) DNA damage [P53, P21, BTG2, MDM2]; and iv) NF-κB pathway [A20, ICAM1]. Using logic-based ordinary differential equation (Logic-ODE), we modelled the dynamic profiles of the different stress responses and extracted specific descriptors potentially predicting the progressive outcomes.
Please see the most updated version on GitHub: https://github.com/saezlab/LogicODE_GFP_SR
创建时间：
2022-08-02
