Crystal structure of Keap1 in complex with a small molecule inhibitor

Crystal structure of Keap1 in complex with a small molecule inhibitor Descriptor: 4-ethoxy-~{N}-[4-[(4-ethoxyphenyl)sulfonylamino]-3-(2-oxidanylidene-2-pyrrol-1-yl-ethyl)naphthalen-1-yl]benzenesulfonamide, FORMIC ACID, Kelch-like ECH-associated protein 1 Authors: Ishida, H, Osawa, M. Deposit date: 2025-04-25 Release date: 2025-09-17 Last modified: 2025-11-19 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Development of Keap1-Nrf2 Protein-Protein Interaction Inhibitor Activating Intracellular Nrf2 Based on the Naphthalene-2-acetamide Scaffold, and its Anti-Inflammatory Effects. Chemmedchem, 20, 2025Keap1与小分子抑制剂结合的晶体结构 描述符：4-乙氧基-N-[4-[(4-乙氧基苯基)磺酰胺基]-3-(2-氧代-2-吡咯-1-基乙基)萘-1-基]苯磺酰胺、甲酸 Kelch样ECH相关蛋白1（Kelch-like ECH-associated protein 1） 作者：Ishida, H、Osawa, M 沉积日期：2025-04-25 发布日期：2025-09-17 最后修改日期：2025-11-19 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.8 Å） 引用文献：《基于萘-2-乙酰胺骨架开发激活胞内Nrf2的Keap1-Nrf2蛋白质相互作用抑制剂及其抗炎作用》，发表于Chemmedchem，第20卷，2025年