Transcriptome sequencing and validation of potential biomarkers associated with cognitive impairment after hypertensive intracerebral hemorrhage

This dataset contains raw paired-end mRNA transcriptome FASTQ sequencing data of peripheral blood mononuclear cells from 9 patients with hypertensive intracerebral hemorrhage (HICH). The purpose of generating these data is to screen for potential therapeutic targets for cognitive impairment after hypertensive intracerebral hemorrhage. 1. Data generation methods:We collected samples from three clinical groups (3 subjects per group: simple hypertension, hemorrhage without cognitive impairment, hemorrhage with cognitive impairment). MoCA scale assessed cognition. mRNA libraries were sequenced on Illumina NovaSeq 6000. Raw reads were processed via bioinformatic pipeline to screen cognitive-related differential genes and hub biomarkers, verified by RT-qPCR on independent samples.2. File contents:The uploaded archive contains 18 compressed FASTQ files:① CI group (hypertensive cerebral hemorrhage with cognitive impairment): CI_1/2/3 paired R1/R2 reads;② NCI group (hypertensive cerebral hemorrhage without cognitive impairment): NCI_1/2/3 paired R1/R2 reads;③ H group ( hypertension): H_1/2/3 paired R1/R2 reads.