Global Genomic Census of Mammalian Adaptation Markers in Highly Pathogenic Avian Influenza A(H5), 2015–2026

The archive contains GenBank/INSDC-derived genomic data, Python analysis scripts, result tables, and figures from a retrospective census of 31,047 H5 influenza isolates (data freeze: December 31, 2025). Twelve mammalian adaptation markers were screened across five viral segments (PB2: E627K, D701N, Q591K, G590S; HA: Q226L, G228S; NA: stalk deletion, H274Y; M1: N30D, T215A; NS1: P42S, D92E) using isolates from GenBank and GISAID EpiFlu. GISAID EpiFlu sequences and raw metadata exports are NOT included (GISAID Data Access Agreement). GISAID data are cited via EPI_SET Identifier EPI_SET_260708rs (https://doi.org/10.55876/gis8.260708rs). The official GISAID Supplemental Acknowledgment Table is included as Data/gisaid_supplemental_table_epi_set_260708rs.pdf.