Detailed COVID-19 Immunology PBL Case Scenario and Group Task Structure : Pyramidal Problem-Based Learning Intervention

This supplementary file provides a detailed description of the educational intervention used in a pyramidal problem-based learning (PBL) activity focused on immunity to COVID-19. It includes the full clinical case scenario, structured group allocation with assigned immunological domains, guided discussion prompts, and the stepwise implementation workflow used during the learning session. The material also outlines the mind-mapping activity framework and the pyramidal integration approach used to progressively develop a systems-level understanding of SARS-CoV-2 immune responses. This includes integration of innate and adaptive immunity, cytokine-mediated inflammation, antibody responses, and immunopathological mechanisms. In addition, the document specifies the expected learning outcomes for students, emphasizing mechanistic reasoning, collaborative learning, and the ability to interpret clinical and laboratory findings from an immunological perspective. This resource is intended to support reproducibility of the teaching intervention and to enable educators to adapt or implement similar problem-based immunology learning activities in other educational settings.