five

T11, AT3, PyMT-M, 2208L GEMM tumors treated with H3B-8800

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE163181
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The objective is to identify splicing and expression changes that occur after spliceosome inhibition in triple-negative breast cancer using immune competent GEMM tumors. 4 different GEMM models of TNBC were transplanted orthotopically into C57BL/6 or Balbc females and then randomized onto 8800 or Vehicle. RNA was obtained from whole tumor. RNA from 3 or 4 biological replicate tumors were sequenced for each model for each condition.
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2020-12-21
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