Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates
收藏Protein Data Bank Japan2024-11-06 更新2026-03-21 收录
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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates Descriptor: 2-{(1S)-1-[(6-chloro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)amino]-2-phenylethyl}pyrido[4,3-d]pyrimidin-4(1H)-one, Beta-secretase 1, ZINC ION Authors: Lougheed, J.C, Brecht, E, Yao, N.H. Deposit date: 2012-11-19 Release date: 2013-03-06 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bioorg.Med.Chem.Lett., 23, 2013
创建时间：
2012-11-19
