Advanced operando mechanochemical studies of polymorphic transitions: the combination of pXRD and acoustic analyses.

In the context of mechanochemistry, the development of original operando analytical techniques (Raman spectroscopy, TRIS pXRD, ssNMR to only cite a few) has been key to help understanding the complex synthetic pathways in the solid-state as well as synthesizing new and exciting materials. Recently, we have developed, in our group, a new non-invasive operando technique based on acoustics. This method allows many chemical transformations as well as rheology changes to be detected, demonstrating the numerous information carried by the sound. More specifically, the complex polymorphic transitions can be surprisingly perceived, as proved in our preliminary tests. In this proposal, we want to combine the powerful TRIS pXRD developed previously at ESRF with our new acoustic system on the syntheses involving two different co-crystals. Each of these chemical systems exhibits various polymorphs and new reaction intermediates of great interests (for pharmaceuticals and MOFs for example).