Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound (Ultrasound Characterizations: Ex-vivo Scanning)

We have demonstrated a more accessible, non-invasive transcranial focused ultrasound pain treatment strategy for senior subjects. This approach involves simultaneously targeting multiple pain-processing circuits using a battery-powered, compact, and low-cost ultrasound analog front end.The dataset includes 2 .mat files with formatted transcranial focused ultrasound pressure scanned through hydrophone in the free water and presence of a freshly excised mouse skull sample (3-dimensional variable: <b>Intensity_locations</b>). Each file name is labeled with the scanning scenarios, i.e., free water vs. mouse skull along with custom-built and battery-operated ultrasound analog front end. The spatial step sizes of the 3D matrix (<b>Intensity_locations</b>) are included in each of these files (variables: step for x and y dimensions, slice for z dimension, physical unit: mm). The pulse duration (PD) is 200 micro-second, and center frequency of the transducer is 500 kHz. The variables <b>xaxis_locations, yaxis_locations, </b>and<b> zaxis_locations</b> described the total step/slice numbers along those three directions.This work was supported in part by NIH EB029354, NS124564, NS131069, and HL147562. More information can be found in the corresponding manuscript:Kim MG, Yeh C-Y, Yu K, Li Z, Gupta K, He B. Analgesic effect of simultaneously targeting multiple pain processing brain circuits in an aged humanized mouse model of chronic pain by transcranial focused ultrasound. APL Bioengineering.If anyone uses the whole or part of the dataset provided here, we kindly ask you to cite the above publication in any of your publications or presentations.