Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a heterologous CAP225 V1V2

Crystal structure of a V2p-reactive RV144 vaccine-like antibody, CAP228-16H, in complex with a heterologous CAP225 V1V2 Descriptor: CAP225 Scaffolded V1V2, CAP228-16H Heavy Chain, CAP228-16H Light Chain, ... Authors: Wibmer, C.K, Moore, P.L, Morris, L. Deposit date: 2018-03-10 Release date: 2018-09-05 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.301 Å) Cite: Common helical V1V2 conformations of HIV-1 Envelope expose the alpha 4 beta 7 binding site on intact virions. Nat Commun, 9, 2018与异源CAP225 V1V2结合的V2p反应性RV144类疫苗抗体CAP228-16H的晶体结构 描述项：CAP225支架化V1V2、CAP228-16H重链、CAP228-16H轻链…… 作者：Wibmer C.K.、Moore P.L.、Morris L. 提交日期：2018-03-10 发布日期：2018-09-05 最后修改日期：2024-11-20 实验方法：X射线衍射（分辨率2.301 Å） 引用文献：HIV-1包膜蛋白常见螺旋V1V2构象可暴露完整病毒颗粒上的α4β7结合位点。《自然-通讯》，9卷，2018年