Identification of genetic markers associated with hyperketonemia patterns in early lactation Holstein cows

<strong>Additional File</strong> <strong>1</strong>- <strong>Table S1. </strong>Descriptive statistics for blood BHB concentration (mmol/L) in Holstein cows were included in an observational study to assess their hyperketonemia patterns in the two weeks postpartum followed by diagnosis and treatment of the condition. <strong>Additional File</strong> <strong>1</strong>- <strong>Table S2. </strong>Results indicated differences in blood BHB concentration (mmol/L) among HYK patterns in Holstein cows were included in an observational study to assess their hyperketonemia patterns in the two weeks postpartum followed by diagnosis and treatment of the condition.<strong> Additional File</strong> <strong>2</strong>- <strong>Spreadsheet S1.</strong> List of genes, SNP and their functional consequences associated with HYK identified through cured vs. control (CUR-CON) contrast. <strong>Spreadsheet S2.</strong> List of genes, SNP and their functional consequences associated with HYK identified through severe vs. control (SEV-CON) contrast. <strong>Spreadsheet S3.</strong> List of genes, SNP and their functional consequences associated with HYK identified through chronic vs. control (CHR-CON) contrast,<strong> Spreadsheet S4.</strong> List of genes, SNP and their functional consequences associated with HYK identified through recurrent vs. control (REC-CON) contrast.<strong> </strong> <strong>Additional File</strong> <strong>3</strong>-<strong> Spreadsheet S1. </strong>Pathways associated with genes identified to cured vs. control (CUR-CON) contrast, <strong>Spreadsheet S2. </strong>Pathways associated with genes identified to severe vs. control (SEV-CON) contrast,<strong> Spreadsheet S3. </strong>Pathways associated with genes identified to chronic vs. control (CHR-CON) contrast,<strong> Spreadsheet S4. </strong>Pathways associated with genes identified to recurrent vs. control (REC-CON) contrast,<strong> Spreadsheet S6.</strong> Pathways associated with genes set identified among 4 analyzed contrasts (Cured-CUR, severe-SEV, chronic-CHR and recurrent-RECU compared with control-CON, respectively), <strong>Spreadsheet S7.</strong> Protein Interaction network associated with genes set identified among 4 analyzed contrasts (Cured-CUR, severe-SEV, chronic-CHR and recurrent-RECU compared with control-CON, respectively). <strong>Additional File</strong> <strong>4</strong>- <strong>Spreadsheet S1.</strong> Go terms and QTL associated with genes and SNPs related to HYK identified through cured vs. control (CUR-CON) contrast analysis, <strong>Spreadsheet S2.</strong> Go terms and QTL associated with genes and SNPs related to HYK identified through severe vs. control (SEV-CON) contrast, <strong>Spreadsheet S3.</strong> Go terms and QTL associated with genes and SNPs related to HYK identified through chronic vs. control (CHR-CON) contrast, <strong>Spreadsheet S4.</strong> Go terms and QTL associated with genes and SNPs related to HYK were identified through recurrent vs. control (REC-CON) contrast.