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Pistol ribozyme transition-state analog vanadate
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2024-03-13
相关数据集
Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reaction
We have performed molecular dynamics (MD) calculations by using one of the recently solved crystal structures of a hammerhead ribozyme. By rotating the α, β, γ, δ, ɛ, and ζ torsion angles of the phosp
PubMed Central1998-09-15 更新60
Crosslinked Hammerhead Ribozyme Initial State
Crosslinked Hammerhead Ribozyme Initial State Descriptor: 5'-R(*GP*CP*CP*GP*AP*AP*AP*CP*UP*CP*GP*UP*AP*AP*GP*AP*GP*UP*CP*AP*CP*CP*AP*C)-3', 5'-R(P*GP*UP*GP*GP*UP*CP*UP*GP*AP*UP*GP*AP*GP*GP*CP*C)-3', C
Protein Data Bank Japan2024-10-16 更新50
Guanosine binding to the Tetrahymena ribozyme: thermodynamic coupling with oligonucleotide binding.
The L-21 Sca I ribozyme derived from the group I intron of Tetrahymena thermophila pre-rRNA catalyzes an endonuclease reaction analogous to the first step of self-splicing. Guanosine (G) is bound by t
PubMed Central1993-09-15 更新20
Toward a Quantum-Chemical Benchmark Set for Enzymatically Catalyzed Reactions: Important Steps and Insights
We present steps toward the construction of a quantum-chemical benchmark set for enzymatically catalyzed reactions comprising differentquite sizablemodel systems for five reactions. Our work is insp
Figshare2019-07-17 更新50
Complexity in pH-Dependent Ribozyme Kinetics: Dark p K a Shifts and Wavy Rate–pH Profiles
Charged bases occur in RNA enzymes, or ribozymes, where they play key roles in catalysis. Cationic bases donate protons and perform electrostatic catalysis, while anionic bases accept protons. We prev
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