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CRISPR Screening of Transcribed Super-Enhancers Identifies Drivers of Triple-Negative Breast Cancer Progression

NIAID Data Ecosystem2026-05-02 收录

三阴性乳腺癌

CRISPRi筛选

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE234328 数据链接链接失效反馈

官方服务：

资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2024-11-14

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raw data for main figures.xlsx

CRISPRi筛选

功能基因组学

data used to create main figures for: Park et. al., Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA, BMC Biol, 2023.

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Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

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Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

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Genes of CRISPR-Cas9 negative screening.

CRISPRi筛选

肿瘤免疫逃逸

We compared changes in sgRNA abundance between T24 cells challenged and unchallenged by CD8+ T cells, and then performed negative screening (p < 0.01, log2Fold change < −1.0, and good sgRNAs ≥ 5). (X

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Genomic Regulation of Invasion by STAT3 in Triple Negative Breast Cancer

三阴性乳腺癌

STAT3转录调控

Breast cancer is a heterogeneous disease comprised of four molecular subtypes defined by whether the tumor-originating cells are luminal or basal epithelial cells. Breast cancers arising from the lumi

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Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

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