Enantioselective One-Pot Synthesis of 2-Amino-4-(indol-3-yl)-4H-Chromenes
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https://figshare.com/articles/dataset/Enantioselective_One_Pot_Synthesis_of_2_Amino_4_indol_3_yl_4_i_H_i_Chromenes/2613700
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资源简介：
An enantioselective one-pot synthesis of 2-amino-4-(indol-3-yl)-4H-chromenes via a Knoevenagel/Pinner/Friedel–Crafts reaction of salicylaldehyde, malononitrile, and indole is presented. Moderate to good yields (up to 89%) and high enantioselectivities (up to 90% ee) were obtained with an N,N′-dioxide–Zn(II) complex as the catalyst. This strategy provides an efficient and convenient method to access enantiomerically enriched 2-amino-4H-chromene derivatives.
创建时间：
2016-02-22
