Selective Approach toward Multifunctionalized Lactams by Lewis Acid Promoted PhSe Group Transfer Radical Cyclization
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https://figshare.com/articles/dataset/Selective_Approach_toward_Multifunctionalized_Lactams_by_Lewis_Acid_Promoted_PhSe_Group_Transfer_Radical_Cyclization/2767609
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资源简介：
We have developed a regiospecific and highly stereoselective strategy for constructing the five-/six-membered monocyclic and bicyclic nitrogen heterocycle skeletons using PhSe group transfer radical cyclization of α-phenylseleno amido esters promoted by a Lewis acid (e.g., Yb(OTf)3) under UV irradiation. We obtained 5-/6-exo-trig mode cyclization products for the N-allyl/homoallyl substrates, whereas the enamide substrate gave 5-endo-trig ring closure.
创建时间：
2010-05-21
