Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1741968196 (A71EV2A-x1068)

Protein Data Bank Japan2024-10-16 更新2026-04-19 收录

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Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1741968196 (A71EV2A-x1068) Descriptor: DIMETHYL SULFOXIDE, PYRIMIDIN-2-AMINE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.11 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16型（Coxsackievirus A16，G-10株）2A蛋白酶晶体片段筛选联合提交沉积——与化合物Z1741968196（编号A71EV2A-x1068）结合的柯萨奇病毒A16型（G-10株）2A蛋白酶晶体结构描述符：二甲基亚砜（DIMETHYL SULFOXIDE）、嘧啶-2-胺（PYRIMIDIN-2-AMINE）、2A蛋白酶（Protease 2A）…… 作者：Lithgo, R.M、Fairhead, M、Koekemoer, L、Balcomb, B.H、Capkin, E、Chandran, A.V、Golding, M、Godoy, A.S、Aschenbrenner, J.C、Marples, P.G、Ni, X、Thompson, W、Tomlinson, C.W.E、Wild, C、Winokan, M、Xavier, M.-A.E、Fearon, D、von Delft, F 提交日期：2024-04-04 发布日期：2024-04-24 末次修改日期：2024-10-16 实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.11埃）引用文献：《柯萨奇病毒A16型2A蛋白酶的晶体片段筛选发现广谱抗肠病毒药物研发新机遇》，BioRxiv，2024

创建时间：

2024-04-04