Additional file 2 of Genetic insights into the association of statin and newer nonstatin drug target genes with human longevity: a Mendelian randomization analysis

Additional file 2: Table S2. Date resources of the exposures and outcomes used in this study. Table S3. The instrumental variables used for circulating lipids in the discovery datasets. Table S4. The instrumental variables used for circulating lipids in the validation datasets. Table S5. Association of circulating lipids with human Lifespan in the discovery and validation datasets. Table S6. Genetically instrumented lipid-lowering genetics variants of target genes in discovery datasets. Table S7. Genetically instrumented lipid-lowering genetics variants of target genes in validation datasets. Table S8. Effects of genetically proxied lipid-lowering variants on Human lifespan. Table S9. Results of heterogeneity and pleiotropy tests for the causal effects of circulating Lipids on human lifespan. Table S10. Sensitivity analysis using different LD r2 thresholds of the Lipid-lowering gene variants. Table S11. Statistical power for drug-target MR analyses. Table S12. Genetic association between the expression of lipid-lowering drug target genes in tissues and human lifespan. Table S13. Colocalization analysis for the serum LDLR expression on Human Lifespan.