Maternal plasma miRNAs as potential biomarkers for detecting risk of SGA

To investigate the miRNA biomarkers asssociated with the Small-for-gestational-age fetuses (SGA) condition, maternal plasma samples from 29 women (N=16 normal, N=13 SGA) were selected to form a discovery cohort in which expression data for a total of 800 miRNAs was determined using the Nanostring nCounter miRNA assay. Differential expression of two miRNA markers; hsa-miR-374a-5p (p = 0•0176) and hsa-let-7d-5p (p = 0•0036), were validated in an independent population of 95 women (SGA n = 12, Control n = 83).