Genome-wide methylation studies in nasal epithelial cells using a custom Asthma&Allergy DNAm array

We performed an epigenome-wide association study (EWAS) of allergic sensitization using nasal epithelial cell DNA from 474 subjects. Nasal epithelial cell methylation patterns were assessed in 474 children ages 5-7 with allergic sensitization as a quantitative trait. Latent factors were estimated in order to account for unobserved variation in the DNA methylation data. The citation for the R package used for latent factor analysis is listed below. FALCO: Factor AnaLysis in COrrelated data McKennan, Chris; https://arxiv.org/abs/2009.11134