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Novel compounds modulating Mycobacterium marinum ESX-5 secretion display anti-mycobacterial activity in vivo

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NIAID Data Ecosystem2026-03-14 收录
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We observed through Western blot that Mycobacterium marinum secreted more highly abundant PE-PGRS proteins that are above 130 kDa when treated with compound 36 than mock-treated bacteria. We would like to explore which PE-PGRS proteins are more secreted in this condition and whether other proteins are also differentially secreted between two conditions.

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2023-01-19
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