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Propargyl-linked DHFR inhibitorsa inhibit the S. aureus and S. pyogenes DHFR enzymes.

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Figshare2015-12-02 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_Propargyl_linked_DHFR_inhibitors_a_inhibit_the_S_aureus_and_S_pyogenes_DHFR_enzymes_/356348
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aThe generalized scaffold for the propargyl-linked inhibitors is shown in Figure 1a.bIC50 values against the DHFR enzymes are reported in nM and represent the average of at least three measurements.cSelectivity is calculated as IC50 (human)/IC50 (pathogen).
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2015-12-02
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