Propargyl-linked DHFR inhibitorsa inhibit the S. aureus and S. pyogenes DHFR enzymes.
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aThe generalized scaffold for the propargyl-linked inhibitors is shown in Figure 1a.bIC50 values against the DHFR enzymes are reported in nM and represent the average of at least three measurements.cSelectivity is calculated as IC50 (human)/IC50 (pathogen).
创建时间：
2015-12-02
