PRISM Repurposing 20Q2 Dataset

<strong>The PRISM Repurposing release contains small molecule viability datasets generated using the Broad Repurposing Library and the PRISM multiplexed cell-line viability assay.</strong> <strong>The primary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 5,274 compounds screened against 578 or 562 cell lines.</strong> <strong>The secondary PRISM Repurposing dataset contains the results of pooled-cell line chemical-perturbation viability screens for 1,448 compounds screened against 489 cell lines in an 8-step, 4-fold dilution, starting from 10uM. Technical redos for 147 previously screened oncology compounds have been added as of 11/22/2019. This data is identified using a `screen_id` of "MTS010". It is recommended to use MTS010 when available. MTS010 was not included in the analysis for Corsello et al. 2019, DOI:10.1101/730119.</strong> <strong>Data processing steps are described in the README files. Further descriptions of methods are available at https://doi.org/10.1101/730119.</strong>PRISM重利用数据集（PRISM Repurposing）收录了依托布罗德重利用文库（Broad Repurposing Library）与PRISM多重细胞系存活率检测技术（PRISM multiplexed cell-line viability assay）生成的小分子化合物存活率数据集。PRISM重利用主数据集包含了针对5274种化合物、在578或562株细胞系中开展的混合细胞系化学扰动存活率筛选结果。PRISM重利用副数据集包含了1448种化合物的混合细胞系化学扰动存活率筛选结果：该批化合物以10μM为起始浓度，经8级4倍梯度稀释后作用于489株细胞系。截至2019年11月22日，数据集新增了147种此前已完成筛选的肿瘤化合物的技术重复数据。该数据集以`screen_id`为"MTS010"进行标识，建议在可用时优先采用MTS010数据集。需注意，MTS010未被纳入Corsello等人2019年的分析研究，该研究的DOI为10.1101/730119。数据集处理步骤详见README文件，相关实验方法的进一步说明可通过DOI：10.1101/730119获取。