mRNA vaccination boosts T cell memory in COVID-19 recovered individual
收藏NIAID Data Ecosystem2026-05-10 收录
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https://immport.org/shared/study/SDY3366
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资源简介：
This study evaluated how prior SARS-CoV-2 infection influences T cell responses elicited by mRNA vaccination. Pre-existing spike-specific memory predicted the magnitude and clonal expansion of CD8+ T cell responses, with the most pronounced boosting observed in individuals carrying HLA-A03:01. In four A03:01 vaccine recipients profiled longitudinally at the single-cell level, progressive exposures through vaccination repeatedly reactivated infection-primed CD8+ T cells and appeared to drive differentiation of responding clones toward a TEMRA-like phenotype while retaining antiviral effector function.
创建时间：
2026-03-26
