Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1270393711 (A71EV2A-x0571)

Group deposition for crystallographic fragment screening of Coxsackievirus A16 (G-10) 2A protease -- Crystal structure of Coxsackievirus A16 (G-10) 2A protease in complex with Z1270393711 (A71EV2A-x0571) Descriptor: 5-(methoxymethyl)-1,2-oxazole-3-carboxamide, DIMETHYL SULFOXIDE, Protease 2A, ... Authors: Lithgo, R.M, Fairhead, M, Koekemoer, L, Balcomb, B.H, Capkin, E, Chandran, A.V, Golding, M, Godoy, A.S, Aschenbrenner, J.C, Marples, P.G, Ni, X, Thompson, W, Tomlinson, C.W.E, Wild, C, Winokan, M, Xavier, M.-A.E, Fearon, D, von Delft, F. Deposit date: 2024-04-04 Release date: 2024-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.01 Å) Cite: Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals. Biorxiv, 2024

柯萨奇病毒A16（Coxsackievirus A16）(G-10株)2A蛋白酶晶体学片段筛选集体提交——柯萨奇病毒A16（G-10株）2A蛋白酶与Z1270393711（A71EV2A-x0571）复合物的晶体结构。描述物：5-(甲氧基甲基)-1,2-恶唑-3-甲酰胺、二甲基亚砜、2A蛋白酶等。作者：Lithgo, R.M.、Fairhead, M.、Koekemoer, L.、Balcomb, B.H.、Capkin, E.、Chandran, A.V.、Golding, M.、Godoy, A.S.、Aschenbrenner, J.C.、Marples, P.G.、Ni, X.、Thompson, W.、Tomlinson, C.W.E.、Wild, C.、Winokan, M.、Xavier, M.-A.E.、Fearon, D.、von Delft, F.。提交日期：2024-04-04；发布日期：2024-04-24；最后修改日期：2024-10-16。实验方法：X射线衍射（分辨率1.01 Å）。引用：《柯萨奇病毒A16 2A蛋白酶晶体学片段筛选发现广谱抗肠病毒研发新机遇》，发表于BioRxiv，2024年。