Classification of Disease Damage and Activity in CLE (JAAD) Supplemental Figures

Supplemental Figure 1. Representative patient clinical photographs demonstrating mild, moderate, and severe disease damage by CLASI-D strata. (A) A 40 year old female with facial lupus erythematosus tumidus (LET) lesions, classified as having mild disease damage (CLASI-D of 0-5). (B) A 23 year old female with disease damage from LET on bilateral thighs (left thigh pictured here) and hyperpigmentation and scarring on bilateral arms (not pictured), classified as moderate disease damage (CLASI-D of 6-16). (C) A 78 year old male with severe disease damage from DLE on scalp (CLASI-D of 17+). Patients have all signed written consent for photography.

Supplemental Figure 2. CLE subtypes in different severity groups of activity and damage. (A-B) Bar graphs compared different categories of CLE disease activity and damage in ACLE (n=28), SCLE (n=33), and DLE patients (n=179). (A) Damage severity was found to be significantly different among disease subtypes (p<0.0001). Patients with DLE were more likely to have severe disease damage. (B) Activity severity did not appear to be significantly associated with any particular subtype (p=0.36).

Abbreviations: ACLE: acute cutaneous lupus erythematosus; DLE: discoid lupus erythematosus; SCLE: subacute cutaneous lupus erythematosus